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In our previous work on combination treatment with an SGLT2 inhibitor and GLP1-RA, we found some baseline characteristics that might identify responders, and relatively low BMI and low insulin secretion were associated with greater bodyweight loss [73]

Targets Hunger Hormones: Reduces cravings and overeating

[DOI] [PubMed] [Google Scholar] 40.Pocai A

If appetite and food noise decrease within the first two weeks on tirzepatide, even at the starting 2.5mg dose, that is a strong positive signal
