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doi:10.1007/s00204-015-1472-2 25
However, in a study that enrolled 28 T2DM patients, the cardiac sympatho-vagal balance (assessed by HR variability) was not affected after 3 or 6 months of exenatide treatment, despite an increase in HR [41]
Patients randomized to immediate-release metformin HCl initiated 500 mg twice daily for 1 week followed by 500 mg with breakfast and 1000 mg with dinner for the second week
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