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A study by Gwin and colleagues found that five days of a 30% caloric deficit required a three-fold increase in EAA intake to maintain a positive whole-body protein balance. When those elevated EAA requirements are not met through diet, the body breaks down muscle protein to supply the necessary amino acidsan outcome that cannot be fully reversed until EAA intake catches up

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Adrian, T

The estimated weight loss difference from placebo at 48 weeks ranged from 6.6 to 22.1 percentage points across the GLP-3R groups
