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Wang et al

The vast majority of the disease's genetic architecture is non-Mendelian, driven by polygenic risk factors interacting with environmental triggers that remains largely uncharacterized [46, 48, 54]

Metformin increases levels of growth differentiation factor 15 (GDF15) in the kidney and circulation to activate glial cell line-derived neurotrophic factor family receptor -like (GFRAL) in the area postrema to reduce body weight

Azathioprine, 6-mercaptopurine (6-MP) [see Warnings and Precautions (5.2)] or MTX may be continued during treatment with HUMIRA if necessary
