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12 GLP-1RAs also upregulate VTA presynaptic dopamine-2 (D2) receptor transcription, ultimately reducing VTA dopaminergic signaling over time

[DOI] [PubMed] [Google Scholar] 233.Buse JB, Vilsboll T, Thurman J, et al

They concentrated on a four-year period, and their conclusions were later published in this 2014 study
