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Safe Laxative Options for Semaglutide and Tirzepatide Users Osmotic laxatives like polyethylene glycol (MiraLAX) and magnesium citrate are generally considered first-line choices for GLP-1 users because they work locally in your colon without systemic absorption

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It is equally possible that NPY is cleaved neuronally by DPP8/DPP9

[DOI] [PubMed] [Google Scholar] 32.Kotronen A., Peltonen M., Hakkarainen A., Sevastianova K., Bergholm R., Johansson L.M., Lundbom N., Rissanen A., Ridderstrle M., Groop L., et al