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(27) found that lowering leptin levels prevented HFD-induced obesity, improved glucose metabolism abnormalities, and ameliorated leptin resistance by restoring hypothalamic sensitivity to leptin signaling

NEJM 2017;377:2063-72 NAFLD: progression of disease Liver histology in NAFLD Histology scoring NAS (NAFLD Activity Score), reflects disease activity: unweighted composite of Steatosis (0 to 3) Lobular inflammation (0 to 3) Ballooning (0 to 2) SAF Score: semi-quantitative score of Steatosis (0 to 3) Activity (lobular inflammation + ballooning) = NAS (0 to 8) Fibrosis (0 to 4) Adapted from Chalasani N

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Previous pregnancies