glp-1 degradation Release and of Figure 4 from Glucagon-like peptide-1:
Description
This combination is often more effective than either approach alone

In this respect, the dual agonist effect of tirzepatide seems to give it a superiority on semaglutide, with a greater decrease (more than 2%) in glycated hemoglobin (A1c), a marker of chronic hyperglycemia (Figure 4)

Mathes et al., 2016)

Supplements, on the other hand, attempt to nudge your body to produce slightly more of its own GLP-1 or to slow its natural breakdown slightly