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Description
2025: Novo Nordisk announced positive Phase 3 ESSENCE trial results for semaglutide in early Alzheimer's disease, reporting statistically significant slowing of cognitive and functional decline a breakthrough data package that could establish GLP-1 therapy as a neuroprotective agent and open an addressable market of 6.5 million Alzheimer's patients in the U.S
[DOI] [PMC free article] [PubMed] [Google Scholar] 159.Grilo C.M., Lydecker J.A., Morgan P.T., Gueorguieva R

The durability and breadth of benefits create more opportunity to escape the cycle of chronic disease

Confounding factors It is important to first note that the majority of articles that were assessed which provided insight into patient demographics reported patients with confounding factors for retained gastric contents and aspiration (Ushakumari and Sladen 2024
