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Warning signs include: Persistent right upper quadrant pain lasting more than 6 hours Fever (temperature above 100.4F or 38C) Severe nausea and vomiting Jaundice (yellowing of skin or eyes) Dark urine or pale stools Tenderness when pressing below the right rib cage Patients should also be aware that sudden severe epigastric pain radiating to the back, especially when accompanied by vomiting, may indicate pancreatitis, including gallstone-induced pancreatitis

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