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These follow-on patents form a systematic attempt to add barriers of entry for generic competitors, with the intention of extending Novo Nordisks market monopoly for as long as possible when the main compound patent on the underlying active ingredient, semaglutide, expires

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The use of reninangiotensin system inhibitors, SGLT-2 inhibitors and novel agents, such as finerenone, have also been shown to slow the progression of DKD to end-stage kidney disease and provide CV protection

Realistic Expectations for Weight Loss in the First Four Weeks First-month weight loss with retatrutide is expected to be modest, as participants begin on a lower titration dose