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This multicenter, double-blind, placebo-controlled trial enrolled people with NAFLD with liver fat content at or above 10% by MRI-PDFF, a FibroScan liver stiffness measure below 10 kPa, alanine aminotransferase (ALT) at or below 75 IU/L, and no diabetes or non-insulin-dependent diabetes with A1C below 9.5%

These cytokines are sufficient and necessary for inducing both astrocyte transformation into neurotoxic A1 and blood-retina barrier destruction, resulting in the subsequent retinal ganglia cell death and various ophthalmopathy (Figure 4

As a retrospective cohort analysis, it is inherently subject to biases such as selection bias

Beta-blockers may mask symptoms of hypoglycaemia (e.g., tremor)