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ICER attributed such denials to cost concerns: supporting these new therapies (even at net prices) creates unprecedented budget impact, and some payers have explicitly chosen not to cover them for weight-loss ( [27] ) ( [36] )

Accordingly, leptin increases insulin sensitivity, specifically insulin-stimulated glucose utilization or glucose oxidation in skeletal muscle and BAT, but this is blunted in WAT [126]

Thus, although GLP-1R/GIPR agonists may result in significant weight loss, the co-administration of dual GLP-1R/GIPR agonists could potentially shield patients from concurrent osteoporosis by exploiting the inherent antiresorptive properties of GIP and GLP-1

Of course, were comparing a Phase 1 result with 12 weeks of data against an approved drug with full Phase 3 evidence