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By 2022, approximately 22.1% of semaglutide prescriptions were off-label, reflecting a significant increase driven by anecdotal reports and celebrity endorsements promoting its efficacy for cosmetic or non-medical weight reduction

Phoenix, AZ: American College of Gastroenterology.

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Owing to the extreme complexity of gut florahost interactions, as well as our knowledge and research capacity, the potential mechanisms underlying such interactions were not explored further, including the relationship between gut microbiota and SCFAs, as well as the mechanisms underlying the effect of specific microbiota on SCFAs