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Semaglutide (Wegovy) recently became the first GLP-1 approved by the FDA to treat adults with MASH with moderate-to-advanced fibrosis, based on the phase 3 ESSENCE trial

Expected timeline to market If the TRIUMPH trials produce results consistent with Phase 2, regulatory submission could occur as early as late next year, with approval and market availability following twelve to eighteen months later

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But for many patients, these medications have led to devastating complications including gastroparesis (stomach paralysis), severe gastrointestinal injury, gallbladder disease, and even pancreatic cancer