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In a 68-week trial, participants experienced an average weight reduction of approximately 14.9%, with about one-third losing over 20% of their initial body weight

Chu X, Liao M, Shen H, Yoshida K, Zur AA, Arya V, Galetin A, Giacomini KM, Hanna I, Kusuhara H, Lai Y, Rodrigues D, Sugiyama Y, Zamek-Gliszczynski MJ, Zhang L, on behalf of the International Transporter Consortium

Additionally, fluctuations in estrogen and progesterone outside the typical cycle can prolong discomfort