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In patients with ASCVD and BMI 30 kg/m, evolocumab was associated with a greater reduction in major adverse cardiovascular events, with a more favorable NNT compared with normal-weight individuals

The duration guide for semaglutide addresses this question in detail

and (iii) planned discontinuation and washout schedule
Consideration for opioid-sparing strategies should also be made due to the known emetogenic effects of opioids and their further reduction of gastric motility
