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[2] [4] Always replace the pen cap after each injection to protect the medication from light

Many patients require doses between 5 mg and 15 mg of tirzepatide per week to sustain weight loss long-term

A 2025 bioRxiv preprint from Yale found that semaglutide alters the dopamine signals surrounding exercise in animal models, which complicates the simple narrative that the drug straightforwardly increases or decreases motivation to move

Each intervention was simulated by varying two model parameters affecting energy intake to fit the observed mean weight loss data