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Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig

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As research has progressed, it has been revealed that vagal sensory neurons distributed in the intestinal and hepatic portal regions play a crucial role in sensing circulating GLP-1 and mediating its physiological actions

The substrate Z-L-arginine 4-methyl-7coumarinylamide was dissolved in HBSS at a concentration of 0.01 mg/mL, and sodium chenodeoxycholate was dissolved at a range of concentrations starting at 100 mg/mL