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Glucose is transported into intestinal L-cells by sodium-glucose cotransporters, and the resultant increase in Ca 2+ influx triggers GLP-1 secretion 32

Glucagon component requires hepatic monitoring The glucagon receptor activity demands monitoring of liver function

Then, more measurable weight loss occurs in the first 2 to 3 months, and increases over 6 to 12 months (SURMOUNT-1)

79 In addition, the development of obesity depends on a diversity of genetic, biological, psychological, sociocultural, and environmental factors
