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However, litigation has unearthed internal emails and studies allegedly showing the manufacturers were aware of these risks long before public disclosure

Higher mean age and baseline SBP, greater use of anti-hypertensive medications, longer T2D duration, and reduction in insulin daily dose might have contributed to explain the difference observed in the impact of weight loss on SBP reduction in these trials, although direct GLP-1R- and GIP-R-mediated effects could also be considered [77]

1 Ribeiro CB, et al

Morosil Citrus Sinensis Fruit Extract: A blood orange extract rich in anthocyanins and polyphenols that supports fat-loss goals, stomach circumference, and lean mass when paired with diet and exercise