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Clinical Importance: Oral semaglutide is the first oral GLP-1 receptor agonist, combining meaningful HbA1c reduction, clinically relevant weight loss, and favorable blood-pressure effects in a once-daily tablet
At 72 weeks, tirzepatide vs semaglutide produced 20.2% weight loss vs 13.7%
Interestingly, the silencing of -catenin with siRNA abolished the effect of Ex-4 on these genes, suggesting dependency on the Wnt/-catenin pathway
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