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They both enhance insulin secretion by the pancreatic islet cells and inhibit glucagon secretion, thereby lowering postprandial blood glucose levels, and have trophic effects on pancreatic -cell mass.6 Endogenous GLP-1 is formed from the cleavage of proglucagon, which is secreted from L cells scattered throughout the intestine but concentrated in the distal ileum

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Glucagon-Like Peptide-1 (GLP-1) and its Cardiovascular Effects Over the past thirty years, researchers have made significant strides in understanding the gut-derived hormones impact on cardiovascular health