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The inner mitochondrial membrane of BAT contains a high density of uncoupling protein 1 (UCP1), which translocates protons to the mitochondrial matrix, uncoupling substrate oxidation from ATP production and generating heat

A 2024 study from Epic Research found that people with hypothyroidism who lost more than 5 pounds while taking GLP-1 medications (including semaglutide) saw TSH (thyroid-stimulating hormone) levels decrease by an average of about 0.55 mU/L

Retrieved January 15, 2026, from Tempia Valenta S, Nicastri A, Perazza F, Marcolini F, Beghelli V, Atti AR, Petroni ML

FDA-approved GLP-1 receptor agonists include semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), lixisenatide (Adlyxin), exenatide (Bydureon BCise), and tirzepatide (Mounjaro, Zepbound)though tirzepatide is technically a dual GIP/GLP-1 receptor agonist