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Researchers are also exploring its potential impact on nonalcoholic fatty liver disease, metabolic syndrome, and cardiovascular risk factors

Hence, there is a continuous need for drugs that are innovative and efficacious like GLP-1 analogues, which have shown superior clinical outcomes and cardiovascular benefits as compared to traditional antidiabetic agents

Tirzepatide did not impact metabolic adaptation during weight loss in people with obesity

Beyond interaction with lipid enzymes, our MS interactome analysis indicates that the GLP-1R binds to ERMCS-localised Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump in the ER and voltage-dependent anion-selective channel protein 2 (VDAC2) in the OMM, both involved in calcium/ion transfer across ERMCSs 90 , suggesting a prominent role for the receptor in the control of intra-organelle ion homoeostasis, with important implications for the regulation of mitochondrial function, ER stress responses and insulin secretion 91