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While the exact cause of PCOS is unknown, factors contributing to its onset include chronic inflammation, higher levels of androgens (male sex hormones that impede ovulation), weight gain, and insulin resistance, a precursor to prediabetes and Type 2 diabetes that impairs the bodys ability to use glucose efficiently

However, after several months at a stable dose, your body may develop partial receptor toleranceyour GLP-1 signaling becomes slightly less pronounced even though the medication dose remains the same

People respond differently to GLP-1s, so treatment should be personalized