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The latter hypothesis derives from observations that GIP modulates vascular tone across peripheral vascular beds by enhancing endothelial nitric-oxide synthesis through eNOS activationan effect abolished by CaMKK, PLC, or AMPK inhibitionand demonstrates anti-inflammatory actions in adipose tissue and endothelium that correlate with increased cAMP signaling in select vascular beds, though a direct cAMP-dependent mechanism underlying its anti-inflammatory effect has yet to be conclusively established 49

Cross-sectional study of perioperative drug and allergen exposure in UK practice in 2016: the 6th National Audit Project (NAP6) Allergen Survey

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