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If the reduction in body weight and the improvement of glycemic control are crucial factors in determining the effects of GLP-1 on NAFLD, direct pharmacological mechanisms could also be involved

These antiinflammatory and antiatherogenic effects of GLP-1 RAs reduce formation of atherosclerotic lesions and progression (59, 60)

After 8 weeks of the HFD, the HFD + NaB group underwent daily intragastric administration of NaB at 200 mg/kg body weight for 8 weeks, while the HFD group received the same amount of saline daily for 8 weeks

Their effects often emerge only in specific physiological contexts, such as exercise, growth, or aging, and may depend on coordinated signaling across multiple tissues