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Jeremy Brown, a research collaborator with CAUSALab, was the corresponding author

However, persistent flushing, severe sweating, fever, rapid heartbeat, or worsening symptoms should still be medically reviewed to rule out other underlying causes

Otherwise, patients taking both a DPP4i and GLP1-RA could benefit from discontinuing the DPP4i

Right now, there are two studies that can shed some light on this: Controlled lab trial (JAMA Psychiatry, 2025) Researchers gave weekly semaglutide injections to 48 adults diagnosed with Alcohol Use Disorder (AUD), meaning they drank at least 7 drinks per week (women) or 14 drinks per week (men), and had at least two heavy-drinking episodes per month (4+ drinks per sitting for women, 5+ for men)