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The effects were inhibited by coinfusion with exendin(939), a specific antagonist of the GLP-1R, indicating that active GLP-1 exerts its vascular protective effects through the classical GLP-1R, which is expressed in vascular smooth muscle cells and endothelial cells

For those with diabetes, GLP-1 and GIP supplements can help control blood sugar

This is partly due to modulation of inflammatory signaling pathways and improvement of mucosal function, for example, by modulating the metabolism of bile acids [18, 19], and by increasing beneficial microbes that support gut homeostasis [4]

The ongoing phase 3 program and TRIUMPH-Outcomes trial will provide definitive safety data