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Increasing evidence has demonstrated that GLP-1 analogues can cross the blood-brain barrier, protect dopaminergic neurons in the substantia nigra, and rescue motor activity and cognitive functions in PD animal models (5961)

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and b) Once activated (with its TM6 open), GLP-1R can activate the G as /AC/cAMP signaling axis robustly and continuously, hence the robust and prolonged cAMP signals GLP-1R (and GCGR) can produce