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While preliminary findings are promising, existing trials remain limited in size and scope, emphasizing the need for standardized, longitudinal human studies integrating multi-omics analyses to establish causality

In the brain, the interaction of GLP-1 or GLP-1RA with the GLP-1R additionally contributes to multi-level control of neuroplasticity mechanisms thus having potential cognitive and affective effects

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While medications like semaglutide focus on a single pathway that helps control appetite and blood sugar, tirzepatide activates two complementary pathways at the same time