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These observational data suggest a potential role for GLP-1 receptor agonists in both the prevention and the treatment of various SUDs, warranting further evaluation

Our studies revealed key signaling mechanisms underlying the role of GPR17 in regulating GLP-1 secretion and suggest future opportunities for pharmacologically targeting GPR17 with inverse agonists to maximize GLP-1 secretion ![Graphical Abstract][1] Graphical Abstract ### Competing Interest Statement The authors have declared no competing interest

GLP-1 agonists and dual agonists can cause hypoglycemia, nausea, and more

D-Allulose, a generally regarded as safe (GRAS) sugar, is rare in nature