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(2016) has shown that when patients receive GLP-1 therapy, there may be reduced activation in brain regions associated with reward processing and motivation when viewing high-calorie food images compared to baseline or placebo conditions

[1] [2] The MHRA SmPC and National Institute for Health and Care Excellence (NICE) Technology Appraisal 875 (TA875) both specify that semaglutide works most effectively when combined with appropriate lifestyle modifications, including dietary changes

Daily totals: 1,200 calories, 130g protein (43%), 95g carbs (32%), 33g fat (25%) At 1,200 calories, every meal does double duty

Many patients who plateau on Semaglutide already switch to Tirzepatide successfully