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The MHRA recommends assessing renal function before starting metformin and monitoring it regularly, particularly in elderly patients or those with declining kidney function

In many cases, only wealthy people will be able to get their hands on obesity treatments, even though the disease disproportionately affects people with lower incomes

Eli Lillys oral small-molecule GLP-1, orforglipron (Foundayo), was FDA-approved April 1, 2026, but it is not tirzepatide and produces less weight loss (11.2% at 72 weeks)

Tirzepatide wins on weight loss efficacy, A1C reduction, injection convenience, side effect tolerability, and increasingly on cost