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The medication starts at 2.5mg and escalates through 5mg, 7.5mg, 10mg, 12.5mg, and up to 15mg

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In fact, its probably the biggest barrier to increasing use of this medication. For physicians, another large challenge when prescribing GLP-1RA medications includes lack of clinical guidelines for offlabel prescribing

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and Eli Lilly, the maker of tirzepatide, the active ingredient in Zepbound, warn about medications claiming to be the compounded versions of brand-name GLP-1 weight-loss drugs

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The concept dates back to the 1830s

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