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The medication starts at 2.5mg and escalates through 5mg, 7.5mg, 10mg, 12.5mg, and up to 15mg

In fact, its probably the biggest barrier to increasing use of this medication. For physicians, another large challenge when prescribing GLP-1RA medications includes lack of clinical guidelines for offlabel prescribing

and Eli Lilly, the maker of tirzepatide, the active ingredient in Zepbound, warn about medications claiming to be the compounded versions of brand-name GLP-1 weight-loss drugs

The concept dates back to the 1830s
