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(1) proopiomelanocortin (POMC) and cocaine-amphetamine-related constructs (CART) neurons activated by peripheral anorexigenic hormones and releasing a-melanocyte-stimulating hormone (alpha-MSH) in satiety center and (2) neurons activated by orexigenic peptides such as ghrelin and orexins that release the substances including neuropeptide Y (NPY), orexins and Agouti-related Peptide (AgrP) in hunger center