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Long-term follow-up data will clarify whether early GLP-1 intervention slows cartilage degeneration and delays or prevents the need for joint replacement surgery

33 In a 48-week smaller trial (n = 71) of semaglutide 2.4 mg once weekly in people with biopsy-confirmed NASH and compensated cirrhosis there was no significant improvement in fibrosis or resolution of NASH compared with placebo