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Because the GLP-1/GIP arms slow gastric emptying, jumping straight to a high dose provokes strong nausea, diarrhea, and vomiting

The combination of effects helps regulate both blood sugar levels and appetite, making it effective for managing type 2 diabetes and supporting weight loss for those overweight or obese

Tirzepatide acts on two (GLP-1 and GIP), which in clinical studies has been associated with greater average weight loss

Doctors use caution when prescribing any of these drugs with Wegovy: diabetes drugs that lower blood sugar, including insulin, sulfonylureas, and meglitinides levothyroxine (Synthroid, Unithroid) beta-blockers selective serotonin reuptake inhibitors (SSRIs) androgens quinolones (a class of antibiotics) salicylates certain diuretics, including furosemide (Lasix) and thiazides Other interactions with Wegovy include certain minerals, supplements, and foods