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Front Immunol 2016;7:394.PubMedPMC 51

Multi-vial projects, dose-titration screens, and SAR series can be quoted with locked lead times and consolidated shipping at the inquiry stage

6 The pharmaceutical industry's opposition to user fees was mitigated, thus clearing a path for the 1992 law, when then FDA commissioner David Kessler worked out an arrangement that met two industry demands: (1) performance goals, which would set target completion times for various review processes, and (2) the promise that these fees would supplementrather than replacefunding that Congress appropriated to FDA

But even splits are not the only option