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P = 0.04
Neither naltrexone nor bupropion, the two medications that make up Contrave, carries a federal scheduling classification under the DEAs Controlled Substances Act

10.1016/j.lfs.2020.118457 59 LiuL.ChenJ.WangL.ChenC.ChenL

And these drugs carry their own side effect profile nausea, gastrointestinal issues, and in rare cases more serious complications that need to be weighed carefully