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This is the mechanistic basis for the "additive rather than redundant" framing the two pathways meet at the mitochondrial output but enter the regulatory web at different upstream points

For patients with diabetes and hypertension, the advantage of DPP-4i is that it regulates blood pressure and improves insulin resistance

JCI insight , 8 (12), e170671

GLP-1s Done the Right Way GLP-1 medications are used strategically to improve insulin sensitivity, reduce inflammation, and support long-term metabolic health, not crash dieting or muscle loss
