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While lixisenatide and exenatide demonstrate relatively rapid and direct action within central circuits, liraglutide and semaglutide may exert their effects more slowly or indirectly, potentially relying on longer systemic exposure, slow diffusion, or action through peripheralcentral pathways

In addition, stabilization of gutbrain signaling and substrate utilization may reduce metabolic stress during sustained energy deficit, thereby supporting a physiological environment more permissive to lean tissue retention

[DOI] [PubMed] [Google Scholar] 65.Willms B, Werner J, Holst JJ, Orskov C, Creutzfeldt W, Nauck MA

Yet despite the runaway popularity of these drugs, not all Mounjaro patients have had positive results
