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Because muscle drives metabolic rate, its loss makes weight regain more likely

CrossRef The Role of Hypoxia-Inducible Factor-1 Alpha in Renal Disease Huixia Liu, Yujuan Li, Jing Xiong Molecules.2022

However, muscle loss can occur without proper exercise, slowing metabolism and reducing strength
The study also indicates a progressive trend, with Wegovy, recognized as the most potent GLP-1 RA, administered at the highest dose and renowned for its remarkable reduction in body weight