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The stimulation of amylase secretion by GLP-1 may not have physiological importance as the concentrations of peptide required are higher than seen in peripheral blood

16 On the other hand, the investigational use of GIPR agonists (GIPRAs) has not yielded similar advantages, partly because of a lack of understanding of GIP dose-response actions

doi: 10.1002/oby.24336

In the phase 2b trial, however, the reductions in glycated hemoglobin and body weight in participants treated with NNC0090-2746 were similar to those in the group treated with liraglutide (76), and no phase 3 trial of NNC0090-2746 has been reported yet