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However, many people find that their body adapts more quickly to each subsequent dose increase because the underlying mechanisms (caloric deficit, metabolic adaptation) are already partially adjusted

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10.1016/S2213-8587(22)00243-1 16 HolstJ

Summary of Timing Nausea typically appears early or after dose increases, and it usually eases over weeks, but the exact course depends on: Drug exposure Meal choices Individual sensitivity Most people cope by making ad hoc adjustmentschanging meal size, adjusting injection timing, or avoiding certain foodswhich is understandable because it feels immediate and within your control