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Whilst Ozempic (semaglutide) does not cause physical dependence or withdrawal symptoms, discontinuing it can lead to significant metabolic changes, particularly for people with type 2 diabetes

Oral GLP-1 formulations Oral semaglutide (Rybelsus) and emerging oral tirzepatide formulations may produce slightly different constipation patterns because the drug passes through the GI tract before absorption

In the STEP 1 trial, participants taking Wegovy alongside diet and exercise lost an average of nearly 15% of their body weight over 68 weeks

Furthermore, slowed gastric motility also impacts drug absorption, potentially affecting medications such as beta-blockers, digoxin, opioids, and antiplatelet drugs