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Insulin doses typically require reduction of 20 to 50 percent when starting tirzepatide to prevent hypoglycemia
Many patients store their pens improperlyin car glove compartments, bathroom medicine cabinets exposed to humidity, or near windows with sunlight exposuredramatically shortening viable shelf life

The treatment algorithm recommended by ADA and EASD is summarized in Figure 3 (72, 73)

Patients should seek immediate care if experiencing severe abdominal pain, nausea, or vomiting
