fda approves first oral glp-1 obesity drug august 1 2025 U.S. FDA approves Wegovy weight-loss
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doi: 10.1007/s43032-019-00026-3 58 ZhuWHanBFanMWangNWangHZhuHet al

More important than net weight loss are changes in body compositionspecifically, reducing body fat while minimizing the loss of lean muscle mass

[DOI] [PubMed] [Google Scholar] 247.Onishi Y., et al

The clinical trials, called LEAD, SUSTAIN, PIONEER, STEP, and SURPASS (youve got to just love the creative acronyms!) have generated data that are hard to dismiss: Glycemic Control : These drugs consistently outperform most oral antidiabetics in lowering blood sugar by 10 to 20 percent
