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The identification of dysregulated incretin secretion and action in both obesity and diabetes led to the revolutionary discovery of incretin-based drugs, such as glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) and dual glucose-dependent insulinotropic peptide (GIP)/GLP-1 RAs [24,25,26,27,28]

Albiglutide Does Not Impair the Counter-Regulatory Hormone Response to Hypoglycaemia: A Randomized, Double-Blind, Placebo-Controlled, Stepped Glucose Clamp Study in Subjects With Type 2 Diabetes Mellitus

Hopefully, this will lead to lower unit cost

It may support weight loss of approximately 23 kg beyond diet alone but requires adherence to a low-fat diet to minimise gastrointestinal side effects